Joseph Cox has a nice program that moves your Windows user profiles to a different hard drive, which can come in very handy if you have an issue with the main hard drive down the road. Sure, the second drive could go out, but the main Windows drive usually is the drive that goes kaput first. Check it out if you have a use for it!
Profile Relocator is a step-based application that allows the re-locating of the Windows Users profile directory. Once re-located, any created profiles will appear in the new location in their entirety. The advantage to doing this allows profiles to be stored in a location that doesn’t reside on the system drive, ensuring that profile data isn’t compromised as a result of re-installation or system failure.